All Client components are impacted for example Pulse client, JSAM,Pulse collaboration, VDI, WTS, Host Checker.
OS affected :Windows and MAC
Browsers impacted :IE,Edge,Chrome,Safari and Firefox
Symptoms :HC will get stuck at loading components.
Pulse collaboration will fail to launch with below error :

WTS,CTS,JSAM etc will fail to launch with below error :
"Failed to contact server."